Ozempic and its like may do a lot of things , but raising the endangerment of suicide does n’t appear to be one of them . explore out this hebdomad is the latest to feel no grounds of a link between GLP-1 drug and suicide .
Scientists at McGill University in Canada conducted the discipline , publishedWednesday in theBritish Medical Journal . They track the wellness event of UK house physician , and failed to find an association between GLP-1 use and an increase risk of suicidality . The finding fall out other major reports from the U.S. and European Union that get hold of a interchangeable conclusion .
The research into a possible connective between GLP-1 use and suicide commence nearly two year ago . In thesummer of 2023 , wellness regulator in the UK , Iceland and the EU reported receiving case reports tying the utilisation of GLP-1 drugs to suicidal ideation . They denote they would conduct a review of the medicament year , which is primarily used to treat type 2 diabetes and fleshiness . In early January 2024 , the FDAupdatedits public list of likely unexampled safety risks associated with approved drug to include this possible hazard .
The GLP-1RA medications Wegovy, Victoza, and Ozempic.© Michael Siluk/UCG/Universal Images Group via Getty
It did n’t take too foresightful for conflicting evidence to emerge , however . after that January , for example , the FDAannouncedthat its own preliminary investigation fail to deform up any signaling of an increased suicide risk . A February 2024 study alsofoundthat people who begin study GLP-1 drug were less probable to be diagnosed with clinical depression and anxiety later on , both key hazard factors for felo-de-se . And in April 2024 , the EU ’s nine - month probe similarlyfound no linkbetween any GLP-1 drug , including semaglutide ( the active constituent in Ozempic and Wegovy ) , and suicide or ideation .
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In this belated research , the McGill investigator analyze aesculapian record from 100 of thousands of UK residents . They compared people who began taking GLP-1s for their diabetes to people taking two other major course of study of diabetes drugs , looking specifically for cover consequence relate to suicidality — a wide category that includes suicidal ideation , ego - harm , and fill in suicides . All in all , they chance no increased risk of suicidality in those on GLP-1 therapy compared to other medicine . They also failed to witness an association between suicidality and GLP-1 use even in mass with a past history of psychiatrical disorder or self - scathe .
It can be very arduous in science to rightfully evidence a negative . And GLP-1 drug certainly are n’t complimentary of other ( andrarely , very serious ) side effects . But impart all the data collected so far — including study suggest that semaglutide use specifically islinkedto alowerrisk of suicide ideation — the finding of fact looks to be fleetly in favour of no add suicide risk from using these drug .
“ These findings should ply some reassurance with respect to the psychiatric base hit of these drugs , ” the McGill researchers wrote .
GLP-1Ozempicsuicides
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